Anti-CDCA2 Antibody (CAB9291)
- SKU:
- CAB9291
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Anti-CDCA2 Antibody (CAB9291)
The CDCA2 Polyclonal Antibody (CAB9291) is a high-quality antibody designed for research involving CDCA2, a cell cycle regulator protein that plays a crucial role in cell division. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. CDCA2, also known as Cell Division Cycle Associated Protein 2, is essential for proper cell division and has been implicated in various cancer types, making it a promising target for cancer research.
The CDCA2 Polyclonal Antibody binds specifically to the CDCA2 protein, allowing for precise detection and analysis in a variety of cell types.Researchers in the fields of oncology and cell biology will find this antibody invaluable for studying the role of CDCA2 in cancer progression and identifying potential therapeutic targets. By understanding the function of CDCA2, scientists can gain insight into the mechanisms of tumor growth and develop targeted therapies to combat cancer.
| Antibody Name: | Anti-CDCA2 Antibody |
| Antibody SKU: | CAB9291 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 724-1023 of human CDCA2 (NP_689775.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | HeLa, Jurkat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 724-1023 of human CDCA2 (NP_689775.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SDSP KPAL TLQQ GQEF SAGG QNAE NLCQ FFKI SPDL NIKC ERKD DFLG AAEG KLQC NRLM PNSQ KDCH CLGD VLIE NTKE SKSQ SEDL GRKP MESS SVVS CRDR KDRR RSMC YSDG RSLH LEKN GNHT PSSS VGSS VEIS LENS ELFK DLSD AIEQ TFQR RNSE TKVR RSTR LQKD LENE GLVW ISLP LPST SQKA KRRT ICTF DSSG FESM SPIK ETVS SRQK PQMA PPVS DPEN SQGP AAGS SDEP GKRR KSFC ISTL ANTK ATSQ FKGY RRRS SLNG KGES SLTA LERI EHNG ERKQ |
| Gene ID: | 157313 |
| Uniprot: | Q69YH5 |
| Cellular Location: | Nucleus |
| Calculated MW: | 7kDa/112kDa |
| Observed MW: | 130kDa |
| Synonyms: | CDCA2, PPP1R81, Repo-Man |
| Background: | This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. |
| NCBI Summary: | This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015] |
| UniProt Code: | Q69YH5 |
| NCBI GenInfo Identifier: | 961658079 |
| NCBI Gene ID: | 157313 |
| NCBI Accession: | NP_001304835.1 |
| UniProt Secondary Accession: | Q69YH5,Q3SX74, Q4G0W0, Q5RKN0, Q69YI4, Q6P464, Q8N7C1 |
| UniProt Related Accession: | Q69YH5 |
| Molecular Weight: | 113 KD |
| NCBI Full Name: | cell division cycle-associated protein 2 isoform 2 |
| NCBI Synonym Full Names: | cell division cycle associated 2 |
| NCBI Official Symbol: | CDCA2Â Â |
| NCBI Official Synonym Symbols: | PPP1R81; Repo-Man  |
| NCBI Protein Information: | cell division cycle-associated protein 2 |
| UniProt Protein Name: | Cell division cycle-associated protein 2 |
| UniProt Synonym Protein Names: | Recruits PP1 onto mitotic chromatin at anaphase protein; Repo-Man |
| Protein Family: | Cell division cycle-associated protein |
| UniProt Gene Name: | CDCA2Â Â |
 | Western blot analysis of extracts of various cell lines, using CDCA2 antibody (CAB9291) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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