The CDC7 Polyclonal Antibody (CAB5738) is a valuable tool for researchers studying the CDC7 protein, a key regulator of cell cycle progression and DNA replication. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CDC7 protein, this antibody enables precise detection and analysis of CDC7 expression in various cell types, making it an essential tool for studies in cancer biology, genomics, and drug development.
CDC7, a atypical protein kinase, plays a crucial role in controlling the initiation of DNA replication and ensuring genomic stability. Dysregulation of CDC7 has been implicated in various types of cancer, making it a promising target for anticancer drug development. By studying the function of CDC7 using this polyclonal antibody, researchers can gain valuable insights into the mechanisms underlying cancer progression and identify potential therapeutic strategies targeting CDC7 for cancer treatment.
Product Name:
CDC7 Rabbit Polyclonal Antibody
SKU:
CAB5738
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 275-574 of human CDC7 (NP_001127892.1).
This gene encodes a cell division cycle protein with kinase activity that is critical for the G1/S transition. The yeast homolog is also essential for initiation of DNA replication as cell division occurs. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Multiple alternatively spliced transcript variants that encode the same protein have been detected.
Purification Method:
Affinity purification
Gene ID:
8317
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDC7 antibody (CAB5738) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
