CDC42EP2 Antibody (PACO25664)
- SKU:
- PACO25664
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CDC42EP2 Antibody (PACO25664)
The CDC42EP2 Polyclonal Antibody (PACO25664) is specially designed for researchers studying CDC42EP2, a protein that plays a role in cell migration and invasion. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the CDC42EP2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for studies in cancer research and cell biology.CDC42EP2, also known as CDC42 effector protein 2, is involved in regulating the activity of the CDC42 GTPase, which in turn impacts cellular processes such as cytoskeletal organization and cell morphology.
Dysregulation of CDC42EP2 has been implicated in cancer progression and metastasis, highlighting its importance as a potential therapeutic target. Researchers interested in understanding the mechanisms underlying cell migration and invasion can benefit from the use of this antibody to further their studies in this field.
| Antibody Name: | CDC42EP2 Antibody (PACO25664) |
| Antibody SKU: | PACO25664 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Cdc42 effector protein 2 protein (9-210AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO25664 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human heart tissue using PACO25664 at dilution of 1:100. |
| Background: | Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. |
| Synonyms: | Cdc42 effector protein 2 (Binder of Rho GTPases 1), CDC42EP2, BORG1 CEP2 |
| UniProt Protein Function: | CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; cytosol; membrane; microtubule cytoskeleton; plasma membrane Molecular Function:GTP-Rho binding; GTPase activator activity; protein binding Biological Process: actin cytoskeleton organization and biogenesis; positive regulation of actin filament polymerization; positive regulation of protein complex assembly; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction |
| NCBI Summary: | CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011] |
| UniProt Code: | O14613 |
| NCBI GenInfo Identifier: | 71152337 |
| NCBI Gene ID: | 10435 |
| NCBI Accession: | O14613.1 |
| UniProt Secondary Accession: | O14613,Q9UNS0, B2RD85, |
| UniProt Related Accession: | O14613 |
| Molecular Weight: | 22,484 Da |
| NCBI Full Name: | Cdc42 effector protein 2 |
| NCBI Synonym Full Names: | CDC42 effector protein 2 |
| NCBI Official Symbol: | CDC42EP2Â Â |
| NCBI Official Synonym Symbols: | CEP2; BORG1Â Â |
| NCBI Protein Information: | cdc42 effector protein 2 |
| UniProt Protein Name: | Cdc42 effector protein 2 |
| UniProt Synonym Protein Names: | Binder of Rho GTPases 1 |
| Protein Family: | Cdc42 effector protein |
| UniProt Gene Name: | CDC42EP2Â Â |
| UniProt Entry Name: | BORG1_HUMAN |
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