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CDC42EP2 Antibody (PACO08319)

SKU:
PACO08319
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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CDC42EP2 Antibody (PACO08319)

The CDC42EP2 Polyclonal Antibody (PACO08319) is specially designed for the detection and analysis of CDC42EP2, a protein involved in cell signaling pathways and cytoskeletal regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to CDC42EP2, researchers can explore its role in various cellular processes and pathways, making it an essential tool for studies in cell biology and molecular biology.CDC42EP2, also known as CDC42 effector protein 2, plays a crucial role in modulating the activity of the small GTPase CDC42, which is involved in cell division, migration, and morphogenesis.

By understanding the function of CDC42EP2, researchers can gain insights into how these cellular processes are regulated and potentially identify new therapeutic targets for diseases such as cancer and neurological disorders. The CDC42EP2 Polyclonal Antibody is a valuable resource for investigating the mechanisms underlying cellular dynamics and behavior.

Antibody Name:CDC42EP2 Antibody (PACO08319)
Antibody SKU:PACO08319
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human CDC42EP2
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:CDC42 effector protein (Rho GTPase binding) 2;CDC42EP2;BORG1;CEP2 ;
UniProt Protein Function:CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; cytosol; membrane; microtubule cytoskeleton; plasma membrane

Molecular Function:GTP-Rho binding; GTPase activator activity; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; positive regulation of actin filament polymerization; positive regulation of protein complex assembly; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction

NCBI Summary:CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011]
UniProt Code:O14613
NCBI GenInfo Identifier:71152337
NCBI Gene ID:10435
NCBI Accession:O14613.1
UniProt Secondary Accession:O14613,Q9UNS0, B2RD85,
UniProt Related Accession:O14613
Molecular Weight:22,484 Da
NCBI Full Name:Cdc42 effector protein 2
NCBI Synonym Full Names:CDC42 effector protein 2
NCBI Official Symbol:CDC42EP2  
NCBI Official Synonym Symbols:CEP2; BORG1  
NCBI Protein Information:cdc42 effector protein 2
UniProt Protein Name:Cdc42 effector protein 2
UniProt Synonym Protein Names:Binder of Rho GTPases 1
Protein Family:Cdc42 effector protein
UniProt Gene Name:CDC42EP2  
UniProt Entry Name:BORG1_HUMAN

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