CDC42EP2 Antibody (PACO02315)
- SKU:
- PACO02315
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CDC42EP2 Antibody (PACO02315)
The CDC42EP2 Polyclonal Antibody (PACO02315) is a valuable tool for research involving CDC42EP2, a protein involved in cellular processes such as cytoskeletal organization and cell migration. This antibody, produced in rabbits, has high specificity and sensitivity for detecting CDC42EP2 in human samples, making it suitable for various research applications such as Western blotting.CDC42EP2, also known as CDC42 effector protein 2, regulates the activity of the small GTPase CDC42, playing a crucial role in cell signaling pathways that control cell morphology and motility. Research on CDC42EP2 is important for understanding its impact on cellular behavior and its potential implications in diseases like cancer, where abnormal cell migration and invasion are major factors in tumor progression.
By using the CDC42EP2 Polyclonal Antibody, researchers can investigate the role of CDC42EP2 in various cellular processes and explore its potential as a target for therapeutic interventions in cancer and other diseases. This antibody provides a reliable tool for studying the function and regulation of CDC42EP2, contributing to advances in cell biology and drug development.
| Antibody Name: | CDC42EP2 Antibody |
| Antibody SKU: | PACO02315 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | synthesized peptide derived from the N-terminal region of human Cdc42EP2. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | CDC42EP2; BORG1; CEP2; Cdc42 effector protein 2; Binder of Rho GTPases 1 |
| UniProt Protein Function: | CDC42EP2: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts in a CDC42-dependent manner. Belongs to the BORG/CEP family. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 11q13 Cellular Component: cytoplasm; cytosol; membrane; microtubule cytoskeleton; plasma membrane Molecular Function:GTP-Rho binding; GTPase activator activity; protein binding Biological Process: actin cytoskeleton organization and biogenesis; positive regulation of actin filament polymerization; positive regulation of protein complex assembly; positive regulation of pseudopodium formation; regulation of cell shape; Rho protein signal transduction |
| NCBI Summary: | CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of CDC42. Coexpression of this protein with CDC42 suggested a role of this protein in actin filament assembly and cell shape control. [provided by RefSeq, Aug 2011] |
| UniProt Code: | O14613 |
| NCBI GenInfo Identifier: | 71152337 |
| NCBI Gene ID: | 10435 |
| NCBI Accession: | O14613.1 |
| UniProt Secondary Accession: | O14613,Q9UNS0, B2RD85, |
| UniProt Related Accession: | O14613 |
| Molecular Weight: | 22,484 Da |
| NCBI Full Name: | Cdc42 effector protein 2 |
| NCBI Synonym Full Names: | CDC42 effector protein 2 |
| NCBI Official Symbol: | CDC42EP2Â Â |
| NCBI Official Synonym Symbols: | CEP2; BORG1Â Â |
| NCBI Protein Information: | cdc42 effector protein 2 |
| UniProt Protein Name: | Cdc42 effector protein 2 |
| UniProt Synonym Protein Names: | Binder of Rho GTPases 1 |
| Protein Family: | Cdc42 effector protein |
| UniProt Gene Name: | CDC42EP2Â Â |
| UniProt Entry Name: | BORG1_HUMAN |
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