The CDC37 Rabbit Monoclonal Antibody (CAB4582) is a vital tool for researchers studying the CDC37 protein, a key molecular chaperone involved in regulating the function of client proteins such as kinases. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting CDC37 in human samples, making it ideal for use in Western blot analyses.CDC37 is essential for maintaining the stability and activity of client proteins, particularly in the context of cell growth, proliferation, and survival pathways.
Dysregulation of CDC37 has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention. By utilizing the CDC37 Rabbit Monoclonal Antibody, researchers can gain valuable insights into the role of CDC37 in cellular processes and disease pathogenesis, ultimately paving the way for the development of novel treatments.
Product Name:
CDC37 Rabbit Monoclonal Antibody
SKU:
CAB4582
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CDC37 (Q16543).
Sequence:
MVDY SVWD HIEV SDDE DETH PNID TASL FRWR HQAR VERM EQFQ KEKE ELDR GCRE CKRK VAEC QRKL KELE VAEG GKAE LERL QAEA QQLR KEER SWEQ
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.
Purification Method:
Affinity purification
Gene ID:
11140
Clone Number:
ARC1040
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CDC37 Rabbit mAb (CAB4582) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
