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CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)

SKU:
CPAB0570
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
PAT3G7AT
Applications:
ELISA
FC
$179
Frequently bought together:

Description

system_update_alt Datasheet

CDC37 Monoclonal Antibody [PAT3G7AT] (CPAB0570)

The CDC37 Polyclonal Antibody (CPAB0570) is a valuable tool for researchers studying the cell division cycle protein 37 (CDC37), a chaperone protein essential for the stability and function of many protein kinases. The antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the CDC37 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for investigations in cancer research and molecular biology.

CDC37 is a critical regulator of protein folding and maturation, playing a pivotal role in the function of protein kinases involved in cell growth and proliferation. Its importance in cancer biology has made it a promising target for therapeutic intervention, with potential implications for the development of novel cancer treatments. Understanding the role of CDC37 in kinase regulation is essential for unraveling the mechanisms underlying tumorigenesis and identifying new strategies for targeted therapy.

Product Name:CDC37 Antibody
Product Sku:CPAB0570
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CDC37 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CDC37 protein 1-378 amino acids purified from Ecoli.
Clone:PAT3G7AT.
Reactivity:Other bodies
Applications:ELISA, Flow Cytometry
Purification Method:CDC37 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG1
Background:CDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1.
Synonyms:P50CDC37, CDC-37, CDC37, Hsp90 co-chaperone Cdc37, Hsp90 chaperone protein kinase-targeting subunit, CDC37A, Cell Division Cycle 37.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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