CDC26 Antibody (PACO38334)
- SKU:
- PACO38334
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
CDC26 Antibody (PACO38334)
The CDC26 Polyclonal Antibody (PAC03834) is a valuable tool for researchers studying CDC26, a key protein involved in cell cycle regulation and cellular proliferation. This antibody, produced in rabbits, demonstrates high specificity and sensitivity when used in Western blot applications, allowing for accurate detection and analysis of CDC26 levels in various cell types.CDC26 is known to interact with other cell cycle regulators, playing a crucial role in maintaining normal cell division and growth. Dysregulation of CDC26 has been implicated in various diseases, including cancer, making it an important target for further investigation.
By understanding the function and regulation of CDC26, researchers can gain insights into potential therapeutic targets for cancer and other proliferative disorders.Overall, the CDC26 Polyclonal Antibody is a reliable tool for researchers interested in studying the role of CDC26 in cellular processes and disease development. Its high reactivity and specificity make it a valuable asset for studies aiming to elucidate the intricate mechanisms of cell cycle control and proliferation.
| Antibody Name: | CDC26 Antibody (PACO38334) |
| Antibody SKU: | PACO38334 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Anaphase-promoting complex subunit CDC26 protein (1-85AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO38334 at dilution of 1:100. |
| Background: | Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. |
| Synonyms: | Anaphase-promoting complex subunit CDC26 (Anaphase-promoting complex subunit 12) (APC12) (Cell division cycle protein 26 homolog), CDC26, ANAPC12 C9orf17 |
| UniProt Protein Function: | CDC26: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the CDC26 family.Chromosomal Location of Human Ortholog: 9q32Cellular Component: nucleoplasm; anaphase-promoting complex; cytosolMolecular Function: protein bindingBiological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8NHZ8 |
| NCBI GenInfo Identifier: | 21281671 |
| NCBI Gene ID: | 246184 |
| NCBI Accession: | NP_644815.1 |
| UniProt Secondary Accession: | Q8NHZ8 |
| UniProt Related Accession: | Q8NHZ8 |
| Molecular Weight: | 9,777 Da |
| NCBI Full Name: | anaphase-promoting complex subunit CDC26 |
| NCBI Synonym Full Names: | cell division cycle 26 |
| NCBI Official Symbol: | CDC26Â Â |
| NCBI Official Synonym Symbols: | APC12; ANAPC12; C9orf17Â Â |
| NCBI Protein Information: | anaphase-promoting complex subunit CDC26; cell division cycle 26 homolog; anaphase-promoting complex subunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphase promoting complex |
| UniProt Protein Name: | Anaphase-promoting complex subunit CDC26 |
| UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog |
| Protein Family: | Anaphase-promoting complex |
| UniProt Gene Name: | CDC26Â Â |
| UniProt Entry Name: | CDC26_HUMAN |
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