UniProt Protein Function: | CDC26: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex. Belongs to the CDC26 family.Chromosomal Location of Human Ortholog: 9q32Cellular Component: nucleoplasm; anaphase-promoting complex; cytosolMolecular Function: protein bindingBiological Process: positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitosis; negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle |
UniProt Protein Details: | |
NCBI Summary: | The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8NHZ8 |
NCBI GenInfo Identifier: | 21281671 |
NCBI Gene ID: | 246184 |
NCBI Accession: | NP_644815.1 |
UniProt Secondary Accession: | Q8NHZ8 |
UniProt Related Accession: | Q8NHZ8 |
Molecular Weight: | 9,777 Da |
NCBI Full Name: | anaphase-promoting complex subunit CDC26 |
NCBI Synonym Full Names: | cell division cycle 26 |
NCBI Official Symbol: | CDC26Â Â |
NCBI Official Synonym Symbols: | APC12; ANAPC12; C9orf17Â Â |
NCBI Protein Information: | anaphase-promoting complex subunit CDC26; cell division cycle 26 homolog; anaphase-promoting complex subunit 12; cell division cycle protein 26 homolog; CDC26 subunit of anaphase promoting complex |
UniProt Protein Name: | Anaphase-promoting complex subunit CDC26 |
UniProt Synonym Protein Names: | Anaphase-promoting complex subunit 12; APC12; Cell division cycle protein 26 homolog |
Protein Family: | Anaphase-promoting complex |
UniProt Gene Name: | CDC26Â Â |
UniProt Entry Name: | CDC26_HUMAN |