The CDC2 Polyclonal Antibody (CAB12414) is a vital tool for researchers studying CDC2, a key regulatory protein involved in cell cycle progression and control. This antibody is produced in rabbits and is highly specific for human samples, making it a reliable choice for Western blot applications. By binding to the CDC2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.CDC2, also known as cell division control protein 2, plays a crucial role in orchestrating cell division and ensuring proper DNA replication.
Dysregulation of CDC2 has been implicated in various diseases, including cancer and developmental disorders. By elucidating the functions of CDC2, researchers can gain valuable insights into these disease processes and potentially identify new therapeutic targets for intervention.Overall, the CDC2 Polyclonal Antibody (CAB12414) is a valuable tool for scientists looking to explore the intricate mechanisms underlying cell cycle regulation and disease development. Its high specificity and reliability make it an essential component for cutting-edge research in molecular and cellular biology.
Product Name:
CDK1 Rabbit Polyclonal Antibody
SKU:
CAB12414
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-297 of human CDK1 (NP_001777.1).
Cytoplasm, Mitochondrion, Nucleus, centrosome, cytoskeleton, microtubule organizing center, spindle.
Calculated MW:
34kDa
Observed MW:
34kDa
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
983
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDK1 Rabbit pAb (CAB12414) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
