The CDC16 Polyclonal Antibody (CAB7197) is a powerful tool for researchers studying CDC16, a key regulator of cell division and cell cycle progression. This high-quality antibody, raised in rabbits, is specifically designed for use in Western blot applications and is highly reactive with human samples.CDC16 is known to play a crucial role in mitosis, controlling the onset of anaphase and ensuring accurate chromosome segregation. Dysregulation of CDC16 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.
With the CDC16 Polyclonal Antibody, researchers can effectively detect and analyze CDC16 protein levels in different cell types, providing valuable insights into cell cycle regulation and potential therapeutic targets for cancer treatment. This antibody is a valuable tool for studies in cell biology, oncology, and drug development.
Product Name:
CDC16 Rabbit Polyclonal Antibody
SKU:
CAB7197
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 371-620 of human CDC16 (NP_003894.3).
Cytoplasm, centrosome, cytoskeleton, microtubule organizing center, spindle.
Calculated MW:
72kDa
Observed MW:
72kDa
The protein encoded by this gene functions as a protein ubiquitin ligase and is a component of the multiprotein APC complex. The APC complex is a cyclin degradation system that governs exit from mitosis by targeting cell cycle proteins for degredation by the 26S proteasome. Each component protein of the APC complex is highly conserved among eukaryotic organisms. This protein, and other APC complex proteins, contain a tetratricopeptide repeat (TPR) domain; a protein domain that is often involved in protein-protein interactions and the assembly of multiprotein complexes. Multiple alternatively spliced transcript variants, encoding distinct proteins, have been identified.
Purification Method:
Affinity purification
Gene ID:
8881
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using CDC16 Rabbit pAb (CAB7197) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
