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CD97 monoclonal antibody (FITC) (AGIM0066)

SKU:
AGIM0066
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
MEM-180
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD97 monoclonal antibody (FITC)
Product Code:AGIM0066
Size:500 µL
Reactivity:Human
Clone:MEM-180
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P48960
Background:CD97 is a G-protein-coupled seven-span transmembrane adhesive receptor that is constitutively expressed on granulocytes and monocytes and rapidly upregulated on T and B cells upon activation. CD97 is produced in alternatively spliced forms and its cellular ligand is CD55 (DAF), which protects various cell types from complement-mediated damage. Interaction of CD97 on leukocytes and CD55 on vessel cells probably facilitate leukocyte activation and migration into the tissues, similarly, CD97 seems to play a role in tumour migration and invasiveness. CD97 is involved in T cell regulation and peripheral granulocyte homeostasis.
UniProt Protein Function:CD97: Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 19p13.12

Cellular Component: focal adhesion; integral to plasma membrane; membrane; plasma membrane

Molecular Function:protein binding; transmembrane receptor activity

Biological Process: cell motility; cell-cell signaling; immune response; inflammatory response

NCBI Summary:This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19. [provided by RefSeq, Jun 2011]
UniProt Code:P48960
NCBI GenInfo Identifier:90110013
NCBI Gene ID:976
NCBI Accession:P48960.4
UniProt Secondary Accession:P48960,O00718, O76101, Q8NG72, Q8TBQ7, A8K7Z4, B2RBJ9
UniProt Related Accession:P48960
Molecular Weight:86,628 Da
NCBI Full Name:CD97 antigen
NCBI Synonym Full Names:adhesion G protein-coupled receptor E5
NCBI Official Symbol:ADGRE5  
NCBI Official Synonym Symbols:CD97; TM7LN1  
NCBI Protein Information:CD97 antigen
UniProt Protein Name:CD97 antigen
UniProt Synonym Protein Names:Leukocyte antigen CD97; CD_antigen: CD97
Protein Family:CD97 antigen
UniProt Gene Name:CD97  
UniProt Entry Name:CD97_HUMAN

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