The CD93 Polyclonal Antibody (PACO18980) is a valuable tool for researchers studying CD93, a glycoprotein receptor involved in immune regulation and cell adhesion. This antibody, produced in rabbits, exhibits high specificity and sensitivity for human samples, making it suitable for a variety of research applications.CD93, also known as C1q receptor, plays a crucial role in immune response modulation by regulating the clearance of apoptotic cells and promoting inflammation. Its involvement in immune signaling pathways makes it a promising target for studying diseases such as cancer, autoimmune disorders, and inflammatory conditions.
The CD93 Polyclonal Antibody (PACO18980) is validated for use in Western blot applications, enabling researchers to detect and analyze CD93 expression in different cell types. By understanding the function of CD93, researchers can gain insights into the mechanisms underlying immune dysregulation and potentially develop novel therapeutic approaches to target this pathway.
Antibody Name:
CD93 Antibody (PACO18980)
Antibody SKU:
PACO18980
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:3000-1:10000, IHC:1:50-1:200
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human CD93
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO18980(CD93 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO18980(CD93 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.
Synonyms:
CD93 molecule
UniProt Protein Function:
CD93: Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
UniProt Protein Details:
Protein type:Membrane protein, integral; Cell adhesion
Chromosomal Location of Human Ortholog: 20p11.21
Cellular Component: cell surface; cytoplasmic membrane-bound vesicle; plasma membrane; integral to membrane
The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
