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CD90 (Thy 1.1) monoclonal antibody (PE) (AGIM0252)

SKU:
AGIM0252
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Mouse
Isotype:
IgG1
Clone:
MRC OX-7
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD90 (Thy 1.1) monoclonal antibody (PE)
Product Code:AGIM0252
Size:500 µL
Reactivity:Mouse
Clone:MRC OX-7
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P04216
Background:CD90 (Thy-1) is an 18-35 kDa GPI-anchored plasma membrane glycoprotein expressed in many cell types, such as in hematopoietic cells and neurons, connective tissues, various fibroblast and stromal cell lines, tumor endothelial cell lines and other. In the mouse, CD90 is expressed mainly on thymocytes and peripheral T lymphocytes. It is involved in T cell activation, cellular adhesion, proliferation and migration, neurite outgrowth, wound healing, apoptosis, and fibrosis. CD90 participates in multiple signaling cascades and its effects are tissue- and cell type-specific. It often functions as an important regulator of cell-cell and cell-matrix interactions.
UniProt Protein Function:THY1: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain.
UniProt Protein Details:

Protein type:Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: anchored to external side of plasma membrane; focal adhesion; growth cone; integral to plasma membrane; endoplasmic reticulum; dendrite; apical plasma membrane; plasma membrane; cytosol; lipid raft; external side of plasma membrane

Molecular Function:integrin binding; protein binding; protein kinase binding

Biological Process: focal adhesion formation; negative regulation of T cell receptor signaling pathway; cytoskeleton organization and biogenesis; T cell receptor signaling pathway; cell-cell adhesion; retinal cone cell development; negative regulation of protein kinase activity; negative regulation of axonogenesis; positive regulation of T cell activation; angiogenesis; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of cell migration; positive regulation of GTPase activity

NCBI Summary:This gene encodes a cell surface glycoprotein and member of the immunoglobulin superfamily of proteins. The encoded protein is involved in cell adhesion and cell communication in numerous cell types, but particularly in cells of the immune and nervous systems. The encoded protein is widely used as a marker for hematopoietic stem cells. This gene may function as a tumor suppressor in nasopharyngeal carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
UniProt Code:P04216
NCBI GenInfo Identifier:20455514
NCBI Gene ID:7070
NCBI Accession:P04216.2
UniProt Secondary Accession:P04216,Q16008, Q9NSP1,
UniProt Related Accession:P04216
Molecular Weight:17,935 Da
NCBI Full Name:Thy-1 membrane glycoprotein
NCBI Synonym Full Names:Thy-1 cell surface antigen
NCBI Official Symbol:THY1  
NCBI Official Synonym Symbols:CD90  
NCBI Protein Information:thy-1 membrane glycoprotein; CDw90; thy-1 antigen; Thy-1 T-cell antigen
UniProt Protein Name:Thy-1 membrane glycoprotein
UniProt Synonym Protein Names:CDw90; Thy-1 antigen; CD_antigen: CD90
Protein Family:Thy-1 membrane glycoprotein
UniProt Gene Name:THY1  
UniProt Entry Name:THY1_HUMAN

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