The CD8a Rabbit Monoclonal Antibody is a high-quality antibody designed for research involving CD8a, a cell surface glycoprotein that serves as a co-receptor for the T cell receptor. This antibody, derived from rabbit monoclonal cells, is highly specific and reactive with human samples, making it ideal for use in various research applications.CD8a is a crucial marker for identifying cytotoxic T cells and plays a key role in immune responses against pathogens and abnormal cells. The CD8a Rabbit Monoclonal Antibody binds specifically to the CD8a protein, allowing for accurate detection and analysis in different cell types. This makes it an essential tool for studying immune responses, T cell activation, and immunological disorders.
With its high specificity and sensitivity, the CD8a Rabbit Monoclonal Antibody is validated for use in techniques such as immunohistochemistry, flow cytometry, and Western blotting. Researchers in immunology, oncology, and infectious diseases can rely on this antibody to accurately identify and study CD8a expression in various biological samples.Overall, the CD8a Rabbit Monoclonal Antibody is a valuable tool for research into T cell biology, immune responses, and immunotherapy development. Its reliable performance and consistent results make it an essential component for studies aiming to understand and manipulate immune cell function in health and disease.
Product Name:
CD8A Rabbit Monoclonal Antibody
SKU:
CAB0663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 136-235 of human CD8A (P01732).
Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:
26kDa
Observed MW:
35kDa
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.
Purification Method:
Affinity purification
Gene ID:
925
Clone Number:
ARC0329
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD8A Rabbit mAb (CAB0663) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
