CD8A Rabbit Polyclonal Antibody (CAB11856)
- SKU:
- CAB11856
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | CD8A Rabbit Polyclonal Antibody |
SKU: | CAB11856 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-182 of human CD8A (NP_001759.3). |
Sequence: | SQFR VSPL DRTW NLGE TVEL KCQV LLSN PTSG CSWL FQPR GAAA SPTF LLYL SQNK PKAA EGLD TQRF SGKR LGDT FVLT LSDF RREN EGYY FCSA LSNS IMYF SHFV PVFL PAKP TTTP APRP PTPA PTIA SQPL SLRP EACR PAAG GAVH TRGL DFAC D |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:100 - 1:500 IHC-P,1:50 - 1:200 |
Synonyms: | CD8; p32; Leu2; CD8alpha; CD8A |
Positive Sample: | THP-1,Mouse spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted, Single-pass type I membrane protein. |
Calculated MW: | 26kDa |
Observed MW: | 26kDa |
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.
Purification Method: | Affinity purification |
Gene ID: | 925 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |