The CD8A Monoclonal Antibody (CAB22219) is a powerful tool for researchers studying CD8A, a critical marker for cytotoxic T cells involved in immune response. This antibody, developed with high specificity, targets the CD8A protein and is optimized for use in various applications such as immunohistochemistry and flow cytometry.CD8A, also known as cluster of differentiation 8 alpha, is essential for the activation of cytotoxic T cells, which play a key role in eliminating virus-infected cells and cancer cells. By targeting CD8A, researchers can gain valuable insights into the function and behavior of cytotoxic T cells in the immune system, making this antibody an invaluable resource for studies in immunology, cancer biology, and infectious diseases.
The CD8A Monoclonal Antibody (CAB22219) provides reliable and reproducible results when used in experiments involving human samples, offering researchers a precise tool for investigating the role of CD8A in various disease contexts. Its high specificity and sensitivity make it an ideal choice for researchers looking to explore the intricacies of immune response and cell-mediated cytotoxicity.
Product Name:
CD8A Monoclonal Antibody
SKU:
CAB22219
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-182 of human CD8A (NP_001759.3).
Cell membrane, Secreted, Single-pass type I membrane protein.
Calculated MW:
21kDa/25kDa/30kDa
Observed MW:
Refer to figures
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.
Purification Method:
Affinity purification
Gene ID:
925
Clone Number:
ARC55249
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human appendix using CD8A Rabbit mAb (CAB22219) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
