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CD81 monoclonal antibody (AGIM0063)

SKU:
AGIM0063
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
M38
Conjugation:
Unconjugated
Applications:
FC
$215
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD81 monoclonal antibody
Product Code:AGIM0063
Size:100 µg in 100 µL
Reactivity:Human
Clone:M38
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:P60033
Background:CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus.
UniProt Protein Function:May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.
NCBI Summary:The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
UniProt Code:P60033
NCBI GenInfo Identifier:38503376
NCBI Gene ID:975
NCBI Accession:P60033.1
UniProt Related Accession:P60033
Molecular Weight:
NCBI Full Name:CD81 antigen
NCBI Synonym Full Names:CD81 molecule
NCBI Official Symbol:CD81  
NCBI Official Synonym Symbols:S5.7; CVID6; TAPA1; TSPAN28  
NCBI Protein Information:CD81 antigen
UniProt Protein Name:CD81 antigen
UniProt Synonym Protein Names:26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81
Protein Family:CD81 antigen
UniProt Gene Name:CD81  

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