The CD80 Rabbit Monoclonal Antibody (CAB19025) is a valuable tool for researchers investigating CD80, a co-stimulatory molecule involved in immune activation and T cell regulation. This antibody, generated using rabbit monoclonal technology, exhibits high specificity and sensitivity when detecting CD80 in human samples, making it suitable for various research applications such as Western blot, immunohistochemistry, and flow cytometry.CD80, also known as B7-1, plays a crucial role in regulating T cell activation and promoting immune responses. Its interaction with CD28 on T cells is essential for providing the second signal required for T cell activation and proliferation.
Dysregulation of the CD80-CD28 pathway has been implicated in various autoimmune diseases, cancer, and inflammatory disorders, highlighting the importance of studying CD80 in these contexts.By using the CD80 Rabbit Monoclonal Antibody (CAB19025), researchers can gain insights into the expression levels, localization, and function of CD80 in different cell types and disease states. This antibody's ability to detect CD80 with high specificity and sensitivity makes it a valuable tool for furthering our understanding of immune regulation and developing targeted therapies for immune-related conditions.
Product Name:
CD80 Rabbit Monoclonal Antibody
SKU:
CAB19025
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 189-288 of human CD80 (P33681).
The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy.
Purification Method:
Affinity purification
Gene ID:
941
Clone Number:
ARC0384
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD80 antibody (CAB19025) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
