The CD74 Polyclonal Antibody (CAB24487) is a valuable tool for researchers studying CD74, a cell surface protein involved in immune response and antigen presentation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the CD74 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential component in studies related to immunology and cancer research.
CD74, also known as the HLA class II histocompatibility antigen, is a key player in the immune system by facilitating the presentation of antigens to immune cells. Its involvement in immune regulation and antigen processing makes it a crucial target for investigations into diseases such as cancer, autoimmune disorders, and infectious diseases. Unraveling the role of CD74 is essential for the development of therapies aimed at modulating immune responses and combating various immune-related conditions.
Product Name:
CD74 Polyclonal Antibody
SKU:
CAB24487
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 56-215 of mouse CD74 (NP_034675.1).
Enables MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including macrophage migration inhibitory factor signaling pathway; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; regulation of T cell differentiation; and thymic T cell selection. Located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Is expressed in lower jaw; lower jaw incisor; lower jaw molar; and thymus primordium. Orthologous to human CD74 (CD74 molecule).
Purification Method:
Affinity purification
Gene ID:
16149
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of Mouse thymus, using CD74 Rabbit pAb (CAB24487) at 1:900 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
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