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Cd74 Antibody (PACO25624)

SKU:
PACO25624
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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Cd74 Antibody (PACO25624)

The CD74 Monoclonal Antibody (PAC025624) is a valuable tool for researchers studying CD74, a cell surface protein involved in antigen presentation and immune response regulation. This antibody, derived from hybridoma cells, exhibits high specificity for human CD74 and is validated for use in various applications, including immunofluorescence and flow cytometry.CD74, also known as the MHC class II-associated invariant chain, plays a crucial role in the immune system by facilitating the loading of antigens onto MHC class II molecules for presentation to T cells. Dysregulation of CD74 expression has been implicated in various diseases, including cancer and autoimmune disorders.

Therefore, studying the expression and function of CD74 using this monoclonal antibody can provide valuable insights into immune-related mechanisms and potentially identify new therapeutic targets.Overall, the PAC025624 CD74 Monoclonal Antibody is a reliable tool for researchers interested in investigating the role of CD74 in immune regulation, antigen presentation, and disease pathogenesis. Its high specificity and versatility in different research applications make it an essential component for studies in immunology, cancer biology, and other related fields.

Antibody Name:Cd74 Antibody (PACO25624)
Antibody SKU:PACO25624
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Mouse
Immunogen:Recombinant Mouse H-2 class II histocompatibility antigen γ chain protein (56-279AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot
Positive WB detected in: Mouse brain tissue
All lanes: Cd74 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 32, 25 kDa
Observed band size: 32 kDa
.
Background:Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/β heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place.
Synonyms:H-2 class II histocompatibility antigen γ chain (Ia antigen-associated invariant chain) (Ii) (MHC class II-associated invariant chain) (CD antigen CD74), Cd74, Ii
UniProt Protein Function:CD74: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74- ROS1 chimeric protein. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Endoplasmic reticulum; Receptor, cytokineCellular Component: cell surface; endoplasmic reticulum; external side of plasma membrane; Golgi apparatus; integral to membrane; integral to plasma membrane; late endosome; lysosome; membrane; MHC class II protein complex; multivesicular body; plasma membrane; vacuoleMolecular Function: beta-amyloid binding; cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; MHC class II protein binding; MHC class II protein binding, via antigen binding groove; nitric-oxide synthase binding; protein bindingBiological Process: activation of MAPK activity; adaptive immune response; antigen processing and presentation; antigen processing and presentation of exogenous peptide antigen via MHC class II; cell proliferation; chaperone cofactor-dependent protein folding; defense response; immune response; immune system process; immunoglobulin mediated immune response; intracellular protein transport; negative regulation of apoptosis; negative regulation of DNA damage response, signal transduction by p53 class mediator; negative regulation of mature B cell apoptosis; negative regulation of peptide secretion; negative regulation of T cell differentiation; negative thymic T cell selection; positive regulation of adaptive immune response; positive regulation of B cell proliferation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of dendritic cell antigen processing and presentation; positive regulation of fibroblast proliferation; positive regulation of innate immune response; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of T cell differentiation; positive regulation of T-helper 2 type immune response; positive thymic T cell selection; prostaglandin biosynthetic process; protein complex assembly; signal transduction
UniProt Protein Details:
NCBI Summary:
UniProt Code:P04441
NCBI GenInfo Identifier:110624770
NCBI Gene ID:16149
NCBI Accession:NP_001036070.1
UniProt Secondary Accession:P04441,O19452
UniProt Related Accession:P04441
Molecular Weight:29.4 kDa
NCBI Full Name:H-2 class II histocompatibility antigen gamma chain isoform 1
NCBI Synonym Full Names:CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
NCBI Official Symbol:Cd74  
NCBI Official Synonym Symbols:Ii; CLIP; DHLAG; HLADG; Ia-GAMMA  
NCBI Protein Information:H-2 class II histocompatibility antigen gamma chain
UniProt Protein Name:H-2 class II histocompatibility antigen gamma chain
UniProt Synonym Protein Names:Ia antigen-associated invariant chain; Ii; MHC class II-associated invariant chain; CD_antigen: CD74
Protein Family:H-2 class II histocompatibility antigen
UniProt Gene Name:Cd74  
UniProt Entry Name:HG2A_MOUSE
ELISA Kits
Mouse H-2 class II histocompatibility antigen gamma chain (Cd74) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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