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CD73 Monoclonal Antibody [P2B6AT] (CPAB0338)

SKU:
CPAB0338
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P2B6AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

CD73 Monoclonal Antibody [P2B6AT] (CPAB0338)

The CD73 Polyclonal Antibody (CPAB0338) is a valuable tool for researchers studying CD73, a key enzyme involved in the production of adenosine, a molecule that plays a crucial role in immune regulation and inflammation. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It binds to the CD73 protein, facilitating its detection in various cell types and tissues.CD73 is known for its immunosuppressive properties, promoting the generation of adenosine to dampen immune responses and maintain tissue homeostasis. In cancer research, CD73 has emerged as a promising therapeutic target due to its role in creating an immunosuppressive tumor microenvironment.

Understanding the expression and function of CD73 is essential for developing new strategies to enhance anti-tumor immune responses and improve cancer immunotherapy outcomes.Overall, the CD73 Polyclonal Antibody is a versatile tool for investigating the role of CD73 in immune regulation, inflammation, and cancer biology. Its high specificity and sensitivity make it an ideal choice for researchers seeking to unravel the complexities of adenosine signaling and its impact on disease pathology.

Product Name:CD73 Antibody
Product Sku:CPAB0338
Size:5μg
Host Species:Mouse
Immunogen:Anti-human CD73 mAb , is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CD73 amino acids 27-252 purified from Ecoli.
Clone:P2B6AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:CD73 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Ecto-5-prime-nucleotidase (5-prime-ribonucleotide phosphohydrolase) catalyzes the conversion of purine 5-prime mononucleotides to nucleosides, the preferred substrate being AMP at a neutral pH. CD73, which consists of a dimer of 2 identical 70kDa subunits, is bound by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane. CD73 is used as a marker of lymphocyte differentiation. Consequently, a deficiency of NT5 occurs in a variety of immunodeficiency diseases. Additional forms of 5-prime nucleotidase exist in the cytoplasm and lysosomes and can be distinguished from ecto-NT5 by their substrate affinities, requirement for divalent magnesium ion, activation by ATP, and inhibition by inorganic phosphate.
Synonyms:5'-nucleotidase, Ecto-5'-nucleotidase, 5'-NT, CD73, NT5E, NT5, NTE, NT, eN, eNT, E5NT.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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