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CD71 monoclonal antibody (APC) (AGIM0484)

SKU:
AGIM0484
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HI166
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD71 monoclonal antibody (APC)
Product Code:AGIM0484
Size:100 µL
Reactivity:Human
Clone:HI166
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P02786
Background:CD71 (transferrin receptor) is a type II transmembrane glycoprotein expressed as homodimer in erythroid blood cell line and in activated leukocytes. CD71 antigen is expressed typically at high level on all proliferating cell, activated cells and erythroblasts or reticulocytes that require iron, but not on resting peripheral blood leucocytes and mature erythrocytes. CD71 antigen is also expressed at high level on cells of most neoplastic cell lines and 29-32% of bone marrow cells. A soluble form of CD71 in serum (plasma) exists besides a membrane form. Monitoring the soluble form of CD71 antigen in plasma is a diagnostic marker of anemia besides assaying plasma ferritin.
UniProt Protein Function:TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.
UniProt Protein Details:

Protein type:Receptor, misc.; Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic membrane-bound vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function:double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity

Biological Process: regulation of cell growth; regulation of cell proliferation; transferrin transport

NCBI Summary:This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]
UniProt Code:P02786
NCBI GenInfo Identifier:108935939
NCBI Gene ID:7037
NCBI Accession:P02786.2
UniProt Secondary Accession:P02786,Q1HE24, Q59G55, Q9UCN0, Q9UCU5, Q9UDF9, Q9UK21 D3DXB0,
UniProt Related Accession:P02786
Molecular Weight:84,871 Da
NCBI Full Name:Transferrin receptor protein 1
NCBI Synonym Full Names:transferrin receptor
NCBI Official Symbol:TFRC  
NCBI Official Synonym Symbols:T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46  
NCBI Protein Information:transferrin receptor protein 1
UniProt Protein Name:Transferrin receptor protein 1
UniProt Synonym Protein Names:T9; p90; CD_antigen: CD71
Protein Family:Transferrin receptor protein
UniProt Gene Name:TFRC  
UniProt Entry Name:TFR1_HUMAN

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