Anti-CD70 Antibody (CAB16809)
- SKU:
- CAB16809
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-CD70 Antibody (CAB16809)
The CD70 Polyclonal Antibody (CAB16809) is a valuable tool for researchers studying CD70, a cell surface protein involved in immune response regulation. Raised in rabbits, this antibody is highly specific for human samples and has been validated for use in Western blot applications. By binding to the CD70 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in immunology and cancer research.CD70, also known as TNFSF7, is a crucial regulator of immune responses, playing a role in T cell activation and proliferation.
Its involvement in immune system function makes it a target of interest for research into diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. By understanding the activity of CD70, researchers may be able to develop innovative therapies that modulate immune responses in these disease contexts, potentially leading to improved treatment options.
| Antibody Name: | Anti-CD70 Antibody |
| Antibody SKU: | CAB16809 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | IF |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of human CD70. |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Mouse, Rat |
| Positive Samples: |
| Immunogen: | A synthetic peptide of human CD70. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 970 |
| Uniprot: | P32970 |
| Cellular Location: | |
| Calculated MW: | 21kDa/23kDa |
| Observed MW: | Refer to figures |
 | Immunofluorescence - CD70 Polyclonal Antibody (CAB16809) |
| Synonyms: | CD70, CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A |
| Background: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. |
| UniProt Protein Function: | CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cytokine Chromosomal Location of Human Ortholog: 19p13 Cellular Component: extracellular space; integral to plasma membrane; plasma membrane Molecular Function:protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32970 |
| NCBI GenInfo Identifier: | 21431837 |
| NCBI Gene ID: | 970 |
| NCBI Accession: | P32970.2 |
| UniProt Secondary Accession: | P32970,Q53XX4, Q96J57, B4DPR8, |
| UniProt Related Accession: | P32970 |
| Molecular Weight: | 193 |
| NCBI Full Name: | CD70 antigen |
| NCBI Synonym Full Names: | CD70 molecule |
| NCBI Official Symbol: | CD70Â Â |
| NCBI Official Synonym Symbols: | CD27L; CD27LG; TNFSF7Â Â |
| NCBI Protein Information: | CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7 |
| UniProt Protein Name: | CD70 antigen |
| UniProt Synonym Protein Names: | CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70 |
| Protein Family: | CD70 antigen |
| UniProt Gene Name: | CD70Â Â |
| UniProt Entry Name: | CD70_HUMAN |
Related Products
Anti-CD70 Antibody (CAB16698)
Vorsetuzumab (Anti-CD70) Biosimilar Antibody
Chongqing Precision (Anti-CD70) Biosimilar Antibody
Anti-Mouse CD70 In Vivo Antibody - Low Endotoxin
Anti-Mouse CD70 [FR70] In Vivo Antibody - Low Endotoxin
Anti-Mouse CD70 [TAN1-7] In Vivo Antibody - Ultra Low Endotoxin
CD70 Rabbit Monoclonal Antibody (CAB20589)
