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CD69 monoclonal antibody (PE) (AGIM0370)

SKU:
AGIM0370
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1/kappa
Clone:
FN50
Conjugation:
PE
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:CD69 monoclonal antibody (PE)
Product Code:AGIM0370
Size:100 µL
Reactivity:Human
Clone:FN50
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1/kappa
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:Q07108
Background:CD69 (C-type lectin domain family 2 C, CLEC2C, also known as AIM) is one of the earliest inducible cell surface molecules acquired during leukocyte activation. This glycoprotein serves as a lectin-type receptor in lymphocytes, NK cells and platelets; it is involved in lymphocyte proliferation. CD69 expression is counteracted on T cells in the AIDS stage of HIV infection, and may be also predictive for clinical response to chemoimmunotherapy.
UniProt Protein Function:Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.
UniProt Protein Details:

Subunit structure: Homodimer; disulfide-linked. Ref.6 Ref.7 Ref.8

Subcellular location: Membrane; Single-pass type II membrane protein.

Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes.

Sequence similarities: Contains 1 C-type lectin domain.

NCBI Summary:This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
UniProt Code:Q07108
NCBI GenInfo Identifier:584906
NCBI Gene ID:969
NCBI Accession:Q07108.1
UniProt Related Accession:Q07108
Molecular Weight:22,559 Da
NCBI Full Name:Early activation antigen CD69
NCBI Synonym Full Names:CD69 molecule
NCBI Official Symbol:CD69  
NCBI Official Synonym Symbols:AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26  
NCBI Protein Information:early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell act
UniProt Protein Name:Early activation antigen CD69
UniProt Synonym Protein Names:Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3
UniProt Gene Name:CD69  
UniProt Entry Name:CD69_HUMAN

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