CD69 monoclonal antibody (APC) (AGIM0483)
- SKU:
- AGIM0483
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG1/kappa
- Clone:
- FN50
- Conjugation:
- APC
- Applications:
- FC
Frequently bought together:
Description
system_update_altDatasheet
| Product Name: | CD69 monoclonal antibody (APC) |
| Product Code: | AGIM0483 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | FN50 |
| Applications: | Flow Cytometry |
| Conjugate: | APC |
| Isotype: | IgG1/kappa |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | Q07108 |
| Background: | CD69 (C-type lectin domain family 2 C, CLEC2C, also known as AIM) is one of the earliest inducible cell surface molecules acquired during leukocyte activation. This glycoprotein serves as a lectin-type receptor in lymphocytes, NK cells and platelets; it is involved in lymphocyte proliferation. CD69 expression is counteracted on T cells in the AIDS stage of HIV infection, and may be also predictive for clinical response to chemoimmunotherapy. |
| UniProt Protein Function: | Function: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets. |
| UniProt Protein Details: | Subunit structure: Homodimer; disulfide-linked. Ref.6 Ref.7 Ref.8 Subcellular location: Membrane; Single-pass type II membrane protein. Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets. Developmental stage: Earliest inducible cell surface glycoprotein acquired during lymphoid activation. Induction: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells. Post-translational modification: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. Sequence similarities: Contains 1 C-type lectin domain. |
| NCBI Summary: | This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q07108 |
| NCBI GenInfo Identifier: | 584906 |
| NCBI Gene ID: | 969 |
| NCBI Accession: | Q07108.1 |
| UniProt Related Accession: | Q07108 |
| Molecular Weight: | 22,559 Da |
| NCBI Full Name: | Early activation antigen CD69 |
| NCBI Synonym Full Names: | CD69 molecule |
| NCBI Official Symbol: | CD69Â Â |
| NCBI Official Synonym Symbols: | AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26Â Â |
| NCBI Protein Information: | early activation antigen CD69; leukocyte surface antigen Leu-23; early T-cell activation antigen p60; early lymphocyte activation antigen; activation inducer molecule (AIM/CD69); C-type lectin domain family 2, member C; CD69 antigen (p60, early T-cell act |
| UniProt Protein Name: | Early activation antigen CD69 |
| UniProt Synonym Protein Names: | Activation inducer molecule; AIM; BL-AC/P26; C-type lectin domain family 2 member C; EA1; Early T-cell activation antigen p60; GP32/28; Leukocyte surface antigen Leu-23; MLR-3 |
| UniProt Gene Name: | CD69Â Â |
| UniProt Entry Name: | CD69_HUMAN |
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