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CD66ecb (CEACAM5/6/8) monoclonal antibody (APC) (AGIM0178)

SKU:
AGIM0178
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 kappa
Clone:
ivi 4/27
Conjugation:
APC
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:CD66ecb (CEACAM5/6/8) monoclonal antibody (APC)
Product Code:AGIM0178
Size:500 µL
Reactivity:Human
Clone:ivi 4/27
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1 kappa
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light
Uniprot:P06731
Background:CEACAMs are highly glycosylated membrane anchored proteins. CEACAM genes make up the CEA family belonging to the immunoglobulin superfamily. CEACAMs are involved in cell adhesion and cell-cell communication processes. CEACAM5 and 6 but NOT CEACAM8 serve as pathogen receptor (e.g. for Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically they are characterized as members of the CD66 cluster of differentiation. Antibodies to CEACAMs are commonly used in immunohistochemistry and flow cytometry to identify cells expressing the glycoproteins. However, CEACAM5 and 6 are also found in serum where they can serve as tumor markers. In adults, CEACAM5 and 6 are expressed in epithelia and CEACAM6 and 8 in granulocytes.
UniProt Protein Function:CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function:identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis

NCBI Summary:Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
UniProt Code:P06731
NCBI GenInfo Identifier:317373456
NCBI Gene ID:1048
NCBI Accession:P06731.3
UniProt Secondary Accession:P06731,H9KVA7,
UniProt Related Accession:P06731
Molecular Weight:76,795 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Synonym Full Names:carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Official Symbol:CEACAM5  
NCBI Official Synonym Symbols:CEA; CD66e  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names:Carcinoembryonic antigen; CEA; Meconium antigen 100
Protein Family:Colicin
UniProt Gene Name:CEACAM5  
UniProt Entry Name:CEAM5_HUMAN

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