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CD66eb (CEACAM5/8) monoclonal antibody (APC) (AGIM0189)

SKU:
AGIM0189
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 kappa.
Clone:
5C8C4
Conjugation:
APC
Applications:
FC
€179
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD66eb (CEACAM5/8) monoclonal antibody (APC)
Product Code:AGIM0189
Size:500 µL
Reactivity:Human
Clone:5C8C4
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1 kappa.
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06731
Background:CD66e, also known as CEACAM5 (Carcinoembryonic antigen-related (CEA) cell adhesion molecule 5, is a glycosyl phosphatidyl inositol- (GPI-) anchored glycoprotein. CEACAM5 and related genes make up the CEA family belonging to the immunoglobulin superfamily. CD66e is involved in cell adhesion. Additionally it serves as pathogen receptor (e.g. Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Antibodies against CEACAM5 are commonly used in immunohistochemistry to identify cells expressing the glycoprotein in tissue samples. However, CEACAM5 is also found in serum where it can be used as a tumor marker. In adults, CEACAM5 is primarily expressed in epithelia of the gastrointestinal tissue commonly together with CEACAM1, CEACAM6 and CEACAM7. CD66b, also known as CEACAM8 is a GPI-anchored glycoprotein as well. CEACAM8 is involved cell-cell communication* but does NOT serve as pathogen receptor. In adults CEACAM8 is expressed in granulocytes together with CEACAM1, CEACAM3 and CEACAM6.
UniProt Protein Function:CEACAM5: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins. Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. Belongs to the immunoglobulin superfamily. CEA family.
UniProt Protein Details:

Protein type:Membrane protein, integral; Immunoglobulin superfamily; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.1-q13.2

Cellular Component: basolateral plasma membrane; integral to plasma membrane

Molecular Function:identical protein binding; protein homodimerization activity

Biological Process: homotypic cell-cell adhesion; negative regulation of apoptosis

NCBI Summary:Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]
UniProt Code:P06731
NCBI GenInfo Identifier:317373456
NCBI Gene ID:1048
NCBI Accession:P06731.3
UniProt Secondary Accession:P06731,H9KVA7,
UniProt Related Accession:P06731
Molecular Weight:76,795 Da
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Synonym Full Names:carcinoembryonic antigen-related cell adhesion molecule 5
NCBI Official Symbol:CEACAM5  
NCBI Official Synonym Symbols:CEA; CD66e  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 5; meconium antigen 100
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 5
UniProt Synonym Protein Names:Carcinoembryonic antigen; CEA; Meconium antigen 100
Protein Family:Colicin
UniProt Gene Name:CEACAM5  
UniProt Entry Name:CEAM5_HUMAN

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