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CD66b (CEACAM8) monoclonal antibody (PE) (AGIM0192)

SKU:
AGIM0192
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 kappa.
Clone:
6/40c
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD66b (CEACAM8) monoclonal antibody (PE)
Product Code:AGIM0192
Size:500 µL
Reactivity:Human
Clone:6/40c
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1 kappa.
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P31997
Background:CD66b, also known as CEACAM8 (Carcinoembryonic antigen-related (CEA) cell adhesion molecule 8, is a glycosyl phosphatidyl inositol- (GPI-) anchored glycoprotein. CD66b and related genes make up the CEA family belonging to the immunoglobulin superfamily. It is involved in cell cell communication*. In contrast to other members of the CEACAM gene family it does NOT serve as pathogen receptor (e.g. for Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically CEACAMs are characterized as members of the CD66 cluster of differentiation. Antibodies to CD66b are commonly used in flow cytometry to distinguish granulocytes from other subtypes of leukocytes (B- and T-cells, NK-cells, Monocytes, DCs) In adults CEACAM8 is expressed in granulocytes together with CEACAM1, CEACAM3 and CEACAM6.
UniProt Protein Function:CEACAM8: Belongs to the immunoglobulin superfamily. CEA family.
UniProt Protein Details:

Protein type:Immunoglobulin superfamily; Membrane protein, integral; Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Biological Process: immune response; blood coagulation; leukocyte migration

UniProt Code:P31997
NCBI GenInfo Identifier:21314600
NCBI Gene ID:1088
NCBI Accession:NP_001807.2
UniProt Secondary Accession:P31997,O60399, Q16574,
Molecular Weight:38,154 Da
NCBI Full Name:carcinoembryonic antigen-related cell adhesion molecule 8
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 8
UniProt Synonym Protein Names:CD67 antigen; Carcinoembryonic antigen CGM6; Non-specific cross-reacting antigen NCA-95
UniProt Gene Name:CEACAM8  
UniProt Entry Name:CEAM8_HUMAN

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