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CD66adecb (CEACAM1/3/5/6/8) monoclonal antibody (APC) (AGIM0167)

SKU:
AGIM0167
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1 kappa
Clone:
6G5j
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD66adecb (CEACAM1/3/5/6/8) monoclonal antibody (APC)
Product Code:AGIM0167
Size:500 µL
Reactivity:Human
Clone:6G5j
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1 kappa
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light
Uniprot:P13688
Background:The monoclonal antibody reacts with an antigen epitope shared by CD66a, b, c, d and e. CD66adecb are members of the CEA (carcinoembryonic antigen) family of the Ig superfamily. CEACAMs (Carcinoembryonic antigen-related (CEA) cell adhesion molecules) are highly glycosylated membrane anchored proteins. CEACAM genes make up the CEA family belonging to the immunoglobulin superfamily. CEACAMs are involved in cell adhesion. Except CEACAM8 they also serve as pathogen receptors (e.g. Helicobacter pylori, Neisseria, Moraxella, Candida albicans). Immunologically they are characterized as members of the CD66 cluster of differentiation. Antibodies against CEACAMs are commonly used in immunohistochemistry and flow cytometry to identify cells expressing the glycoprotein in tissue samples and cell culture. However, CEACAM1, 5 and 6 are also found in serum where they can be used as tumor markers. In adults, CEACAM1, 5, and 6 are expressed in some epithelia, CEACAM1, 3, 6 and 8 in granulocytes and CEACAM1 in defined microvascular endothelial cells. CD66a (CEACAM1) is mainly expressed on granulocytes, binds to CD66a,c e and CD62E. CD66b (CEACAM8) is expressed exclusively on granulocytes and used as granulocyte marker. It has been reported to induce activation in neutrophils and to be involved in heterophilic adhesion with CD66c. CD66c (CEACAM6) is expressed on granulocytes and epithelial cells. The ligands of CD66c are CD66a-e, CD62E and Galectins. CD66d (CEACAM3) is expressed by neutrophils and serves as a microbial receptor for a wide range of microorganisms. CD66e molecule is also called (CEACAM5) is primarily found on epithelial cells. CD66e binds to CD66a, c and e.
UniProt Protein Function:CEACAM1: carcinoembryonic antigen-related cell adhesion molecule 1. A cell-cell adhesion molecule that directly associates with annexin II. Has tumor suppressor activity in prostate carcinoma. Belongs to the immunoglobulin superfamily and the CEA family. Abundantly expressed in epithelia, vessel endothelia, trophoblasts, platelets and neutrophilic granulocytes. Also present in many cell types of the immune system such as B cells, T cells, NK cells, macrophages and dendritic cells. Five alternatively spliced isoforms have been described. Two isoforms are type I membrane proteins, while three are secreted.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Immunoglobulin superfamily; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: membrane; integral to plasma membrane; integral to membrane; plasma membrane

Molecular Function:protein binding; protein homodimerization activity

Biological Process: integrin-mediated signaling pathway; cell migration; angiogenesis; homophilic cell adhesion; blood coagulation; leukocyte migration

NCBI Summary:This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
UniProt Code:P13688
NCBI GenInfo Identifier:399116
NCBI Gene ID:634
NCBI Accession:P13688.2
UniProt Related Accession:P13688
Molecular Weight:
NCBI Full Name:Carcinoembryonic antigen-related cell adhesion molecule 1
NCBI Synonym Full Names:CEA cell adhesion molecule 1
NCBI Official Symbol:CEACAM1  
NCBI Official Synonym Symbols:BGP; BGP1; BGPI  
NCBI Protein Information:carcinoembryonic antigen-related cell adhesion molecule 1
UniProt Protein Name:Carcinoembryonic antigen-related cell adhesion molecule 1
UniProt Synonym Protein Names:Biliary glycoprotein 1; BGP-1; CD_antigen: CD66a
Protein Family:CEACAM1-like protein
UniProt Gene Name:CEACAM1  
UniProt Entry Name:CEAM1_HUMAN

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