The CD63 Polyclonal Antibody (CAB5271) is a critical tool for researchers studying CD63, a cell surface protein involved in various cellular processes such as cell adhesion, migration, and signaling. This antibody, produced in rabbits, is highly specific for human samples and is validated for use in Western blot applications. It binds to the CD63 protein, allowing for the detection and analysis of this important molecule in a wide range of cell types.CD63, a member of the tetraspanin family, is known to play a key role in intracellular trafficking and exosome formation. Its expression has been linked to cancer progression, metastasis, and drug resistance, making it a valuable target for research in oncology.
By studying the function and regulation of CD63, researchers can gain insights into the mechanisms underlying these processes and potentially identify novel therapeutic strategies for cancer treatment.In addition, CD63 has been implicated in immune responses, including antigen presentation and T cell activation. Its involvement in these pathways makes it a potential target for immunotherapy research and the development of novel treatments for immune-related disorders. By using the CD63 Polyclonal Antibody (CAB5271), researchers can further elucidate the role of CD63 in these processes and advance our understanding of its significance in both health and disease.
Product Name:
CD63 Polyclonal Antibody
SKU:
CAB5271
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 103-203 of human CD63 (NP_001771.1).
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms.
Purification Method:
Affinity purification
Gene ID:
967
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from A375 cells, using CD63 Rabbit pAb (CAB5271) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
