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Anti-CD6 Antibody (CAB8107)

SKU:
CAB8107
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
€139 - €419
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Description

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Antibody Name:CD6 Rabbit Polyclonal Antibody
Antibody SKU:CAB8107
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 424-668 of human CD6 (NP_006716.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7, Jurkat, U-937, HT-29, Raji
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 424-668 of human CD6 (NP_006716.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LRIK GKYA LPVM VNHQ HLPT TIPA GSNS YQPV PITI PKEV FMLP IQVQ APPP EDSD SGSD SDYE HYDF SAQP PVAL TTFY NSQR HRVT DEEV QQSR FQMP PLEE GLEE LHAS HIPT ANPG HCIT DPPS LGPQ YHPR SNSE SSTS SGED YCNS PKSK LPPW NPQV FSSE RSSF LEQP PNLE LAGT QPAF SAGP PADD SSST SSGE WYQN FQPP PQPP SEEQ FGCP GSPS PQPD STDN DDYD DISA A
Gene ID:923
Uniprot:P30203
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:58kDa/60kDa/63kDa/64kDa/68kDa/71kDa
Observed MW:110kDa
Synonyms:CD6, TP120
Background:This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane

Molecular Function:protein binding; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; cell adhesion

NCBI Summary:This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
UniProt Code:P30203
NCBI GenInfo Identifier:281185506
NCBI Gene ID:923
NCBI Accession:P30203.3
UniProt Secondary Accession:P30203,Q9UMF2, Q9Y4K7, Q9Y4K8, Q9Y4K9, Q9Y4L0, A4KAD4 A4KAD5,
UniProt Related Accession:P30203
Molecular Weight:60,572 Da
NCBI Full Name:T-cell differentiation antigen CD6
NCBI Synonym Full Names:CD6 molecule
NCBI Official Symbol:CD6  
NCBI Official Synonym Symbols:TP120  
NCBI Protein Information:T-cell differentiation antigen CD6; T12; CD6 antigen
UniProt Protein Name:T-cell differentiation antigen CD6
UniProt Synonym Protein Names:T12; TP120; CD_antigen: CD6
Protein Family:T-cell differentiation antigen
UniProt Gene Name:CD6  
UniProt Entry Name:CD6_HUMAN

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