CD59 Rabbit Monoclonal Antibody (CAB4090)
- SKU:
- CAB4090
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | CD59 Rabbit Monoclonal Antibody |
SKU: | CAB4090 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 49-128 of human CD59 (NP_000602.1). |
Sequence: | DACL ITKA GLQV YNKC WKFE HCNF NDVT TRLR ENEL TYYC CKKD LCNF NEQL ENGG TSLS EKTV LLLV TPFL AAAW SLHP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | 1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20; CD59 |
Positive Sample: | HT-29, Hep G2, Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Secreted |
Calculated MW: | 14kDa |
Observed MW: | 16kDa |
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Purification Method: | Affinity purification |
Gene ID: | 966 |
Clone Number: | ARC0896 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |