The CD59 Rabbit Monoclonal Antibody (CAB4090) is a powerful tool for researchers studying CD59, a key protein involved in immune system regulation. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By targeting the CD59 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in immunology and cancer research.CD59, also known as protectin, is known for its role in protecting cells from complement-mediated damage by inhibiting the formation of the membrane attack complex.
Dysregulation of CD59 has been implicated in various diseases, including cancer and autoimmune disorders. By understanding the function of CD59, researchers can potentially develop new therapeutic strategies for these conditions.Overall, the CD59 Rabbit Monoclonal Antibody (CAB4090) is a reliable and sensitive tool for investigating the role of CD59 in immune response modulation and disease pathogenesis.
Product Name:
CD59 Rabbit Monoclonal Antibody
SKU:
CAB4090
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 49-128 of human CD59 (NP_000602.1).
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
Purification Method:
Affinity purification
Gene ID:
966
Clone Number:
ARC0896
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD59 Rabbit mAb (CAB4090) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
