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CD59 (no azide) monoclonal antibody (AGIM0054)

SKU:
AGIM0054
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
MEM-43
Conjugation:
Unconjugated
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD59 (no azide) monoclonal antibody
Product Code:AGIM0054
Size:100 µg in 100 µL
Reactivity:Human
Clone:MEM-43
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgG2a
Host Species:Mouse
Storage:Aliquot and store at -20°C. Avoid freeze/thaw cycles. Should be handled underaseptic conditions.
Uniprot:P13987
Background:CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). It is thus the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 associates with C5b-8 complex and thereby counteracts appropriate formation of cytolytic pore within the plasma membrane. CD59 is also an low-affinity ligand of human CD2 and causes T cell costimulation. This material is offered for research only. Not for use in human. For in vitro use only. ImmunoTools will not be held responsible for patent infringement or other violations that may occur with the use of our products.
UniProt Protein Function:CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; vesicle

Molecular Function:complement binding; protein binding

Biological Process: blood coagulation; cell activation; cell surface receptor linked signal transduction; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; neutrophil degranulation; regulation of complement activation

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy

NCBI Summary:This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P13987
NCBI GenInfo Identifier:116021
NCBI Gene ID:966
NCBI Accession:P13987.1
UniProt Related Accession:P13987
Molecular Weight:14kDa
NCBI Full Name:CD59 glycoprotein
NCBI Synonym Full Names:CD59 molecule (CD59 blood group)
NCBI Official Symbol:CD59  
NCBI Official Synonym Symbols:1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20  
NCBI Protein Information:CD59 glycoprotein
UniProt Protein Name:CD59 glycoprotein
UniProt Synonym Protein Names:1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
Protein Family:CD59 glycoprotein
UniProt Gene Name:CD59  

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