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CD56 monoclonal antibody (PE) (AGIM0367)

SKU:
AGIM0367
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
B-A19
Conjugation:
PE
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD56 monoclonal antibody (PE)
Product Code:AGIM0367
Size:100 µL
Reactivity:Human
Clone:B-A19
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P13591
Background:CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of immunoglobulin family serving as adhesive molecule which is ubiquitously expressed in nervous system, usually as 120 kDa, 140 kDa or 180 kDa isoform, and it is also found on T cells and NK cells. Polysialic modification results in reduction of CD56-mediated cell adhesion and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumours and ovarian granulosa cell tumours.
UniProt Protein Function:NCAM1: This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. 6 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q23.1

Cellular Component: Golgi membrane; cell surface; membrane; integral to membrane; plasma membrane; external side of plasma membrane

Molecular Function:identical protein binding

Biological Process: axon guidance; extracellular matrix organization and biogenesis; cytokine and chemokine mediated signaling pathway; cell adhesion

NCBI Summary:This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
UniProt Code:P13591
NCBI GenInfo Identifier:205830665
NCBI Gene ID:4684
NCBI Accession:P13591.3
UniProt Related Accession:P13591
Molecular Weight:
NCBI Full Name:Neural cell adhesion molecule 1
NCBI Synonym Full Names:neural cell adhesion molecule 1
NCBI Official Symbol:NCAM1  
NCBI Official Synonym Symbols:CD56; NCAM; MSK39  
NCBI Protein Information:neural cell adhesion molecule 1
UniProt Protein Name:Neural cell adhesion molecule 1
UniProt Synonym Protein Names:CD_antigen: CD56
UniProt Gene Name:NCAM1  
UniProt Entry Name:NCAM1_HUMAN

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