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CD55 monoclonal antibody (PE) (AGIM0366)

SKU:
AGIM0366
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
HI55a
Conjugation:
PE
Applications:
FC
$215
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Description

system_update_altDatasheet
Product Name:CD55 monoclonal antibody (PE)
Product Code:AGIM0366
Size:100 µL
Reactivity:Human
Clone:HI55a
Applications:Flow Cytometry
Conjugate:PE
Isotype:IgG2a
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P08174
Background:CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
UniProt Protein Function:CD55: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Belongs to the receptors of complement activation (RCA) family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, GPI anchor; Cell surface

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: cell surface; integral to plasma membrane; extracellular region; plasma membrane; lipid raft

Molecular Function:viral receptor activity; protein binding; lipid binding

Biological Process: respiratory burst; entry of virus into host cell; elevation of cytosolic calcium ion concentration; negative regulation of complement activation; regulation of complement activation; innate immune response; regulation of lipopolysaccharide-mediated signaling pathway; complement activation, classical pathway

Disease: Blood Group, Cromer System

NCBI Summary:This gene encodes a protein involved in the regulation of the complement cascade. The encoded glycoprotein is also known as the decay-accelerating factor (DAF); binding of DAF to complement proteins accelerates their decay, disrupting the cascade and preventing damage to host cells. Antigens present on the DAF glycoprotein constitute the Cromer blood group system (CROM). Two alternatively spliced transcripts encoding different proteins have been identified. The predominant transcript encodes a membrane-bound protein expressed on cells exposed to plasma component proteins but an alternatively spliced transcript produces a soluble protein present at much lower levels. Additional, alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:P08174
NCBI GenInfo Identifier:10835143
NCBI Gene ID:1604
NCBI Accession:NP_000565.1
UniProt Secondary Accession:P08174,P09679, P78361, B1AP14, D3DT83, D3DT84,
UniProt Related Accession:P08174
Molecular Weight:41,400 Da
NCBI Full Name:complement decay-accelerating factor isoform 1 preproprotein
NCBI Synonym Full Names:CD55 molecule, decay accelerating factor for complement (Cromer blood group)
NCBI Official Symbol:CD55  
NCBI Official Synonym Symbols:CR; TC; DAF; CROM  
NCBI Protein Information:complement decay-accelerating factor; CD55 antigen
UniProt Protein Name:Complement decay-accelerating factor
Protein Family:Complement decay-accelerating factor
UniProt Gene Name:CD55  
UniProt Entry Name:DAF_HUMAN

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