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CD5 monoclonal antibody (APC) (AGIM0455)

SKU:
AGIM0455
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HISM2
Conjugation:
APC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD5 monoclonal antibody (APC)
Product Code:AGIM0455
Size:100 µL
Reactivity:Human
Clone:HISM2
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P06127
Background:CD5 antigen is a human cell surface T-lymphocyte single-chain transmembrane glycoprotein. CD5 is expressed on all mature T-lymphocytes, most of thymocytes, subset of B-lymphocytes and on many Tcell leukemias and lymphomas. It is a type I membrane glycoprotein whose extracellular region contains three scavenger receptor cysteine-rich (SRCR) domains. The CD5 is a signal transducing molecule whose cytoplasmic tail is devoid of any intrinsic catalytic activity. CD5 modulates signaling through the antigen-specific receptor complex (TCR and BCR). CD5 crosslinking induces extracellular Ca++ mobilization, tyrosine phosphorylation of intracellular proteins and DAG production. Preliminary evidence shows protein associations with ZAP-70, p56lck, p59fyn, PC-PLC, etc. CD5 may serve as a dual receptor, giving either stimulatory or inhibitory signals depending both on the cell type and development stage. In thymocytes and B1a cells seems to provide inhibitory signals, in peripheral mature T lymhocytes it acts as a costimulatory signal receptor. CD5 is the phenotypic marker of a B cell subpopulation involved in the production of autoreactive antibodies.
UniProt Protein Function:CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains.
UniProt Protein Details:

Protein type:Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function:protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity

Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition

UniProt Code:P06127
NCBI GenInfo Identifier:313104090
NCBI Gene ID:921
NCBI Accession:P06127.2
UniProt Secondary Accession:P06127,A0N0P4, A8K9I3,
UniProt Related Accession:P06127
Molecular Weight:459
NCBI Full Name:T-cell surface glycoprotein CD5
NCBI Synonym Full Names:CD5 molecule
NCBI Official Symbol:CD5  
NCBI Official Synonym Symbols:T1; LEU1  
NCBI Protein Information:T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1
UniProt Protein Name:T-cell surface glycoprotein CD5
UniProt Synonym Protein Names:Lymphocyte antigen T1/Leu-1; CD_antigen: CD5
Protein Family:CD5 antigen
UniProt Gene Name:CD5  
UniProt Entry Name:CD5_HUMAN

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