CD48 Polyclonal Antibody (CAB5396) is a valuable tool for research involving the CD48 protein, a cell surface molecule known for its role in immune response regulation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the CD48 protein, this antibody allows for the detection and analysis of CD48 in various cell types, making it an essential component for studies in immunology and cancer research.CD48, also referred to as a signaling lymphocytic activation molecule, is a key player in immune system function, playing a crucial role in the activation and regulation of immune responses.
Understanding the role of CD48 is vital for investigating diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions, where immune dysregulation is a significant factor. By targeting CD48, researchers can gain insights that may lead to the development of novel therapies aimed at modulating immune responses in these pathological conditions.
Product Name:
CD48 Rabbit Polyclonal Antibody
SKU:
CAB5396
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 45-210 of human CD48 (NP_001769.2).
This gene encodes a member of the CD2 subfamily of immunoglobulin-like receptors which includes SLAM (signaling lymphocyte activation molecules) proteins. The encoded protein is found on the surface of lymphocytes and other immune cells, dendritic cells and endothelial cells, and participates in activation and differentiation pathways in these cells. The encoded protein does not have a transmembrane domain, however, but is held at the cell surface by a GPI anchor via a C-terminal domain which maybe cleaved to yield a soluble form of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
962
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using CD48 antibody (CAB5396) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 5 min.
