The CD47 Polyclonal Antibody (CAB7278) is a valuable tool for researchers studying CD47, a cell surface protein that plays a crucial role in immune regulation and the prevention of phagocytosis. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the CD47 protein, this antibody allows for the detection and analysis of CD47 expression in various cell types, making it an essential component for studies in immunology and cancer research.CD47, also known as integrin-associated protein, is involved in a variety of cellular processes, including the regulation of apoptosis, adhesion, and migration. Its function as a "don't eat me" signal to phagocytic cells is particularly important in the context of cancer, where overexpression of CD47 can help tumor cells evade immune detection and destruction.
Research into CD47 and its interactions with immune cells is critical for the development of novel immunotherapies and targeted treatments for cancer and other diseases.The CD47 Polyclonal Antibody (CAB7278) offers researchers a reliable tool for investigating the role of CD47 in immune regulation and disease pathogenesis. By providing accurate and specific detection of CD47 protein levels, this antibody enables detailed studies into the mechanisms by which CD47 influences immune responses and maintains cellular homeostasis. With its proven performance in Western blot applications, this antibody is a valuable asset for advancing our
Product Name:
CD47 Rabbit Polyclonal Antibody
SKU:
CAB7278
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 20-140 of human CD47 (NP_001768.1).
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
961
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD47 Rabbit pAb (CAB7278) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
