The CD47 Polyclonal Antibody (CAB1838) is a valuable tool for researchers studying CD47, a cell surface protein known for its roles in immune evasion and cancer progression. This antibody, derived from rabbits, is highly specific to human samples and has been validated for use in Western blotting applications. By binding to the CD47 protein, this antibody enables accurate detection and analysis in various cell types, making it an essential component for studies in immunology and oncology.CD47, also known as integrin-associated protein, plays a crucial role in inhibiting phagocytosis and promoting tumor immune evasion. Its overexpression has been linked to poor prognosis in various cancers, making it a promising target for anti-cancer therapies.
Furthermore, CD47's involvement in immune regulation and its interaction with SIRPα on phagocytic cells highlight its significance in modulating immune responses and inflammatory processes.Understanding the function and mechanisms of CD47 is essential for developing novel approaches to cancer treatment and immunotherapy. The CD47 Polyclonal Antibody (CAB1838) provides researchers with a reliable tool to investigate the complex role of CD47 in disease progression and immune modulation, paving the way for innovative therapeutic strategies.
Product Name:
CD47 Rabbit Polyclonal Antibody
SKU:
CAB1838
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 224-323 of human CD47 (NP_001768.1).
This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
961
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD47 Rabbit pAb (CAB1838) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
