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CD47 monoclonal antibody (AGIM0048)

SKU:
AGIM0048
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgM
Clone:
MEM-122
Conjugation:
Unconjugated
Applications:
FC
$215
Frequently bought together:

Description

system_update_altDatasheet
Product Name:CD47 monoclonal antibody
Product Code:AGIM0048
Size:100 µg in 100 µL
Reactivity:Human, Porcine
Clone:MEM-122
Applications:Flow Cytometry
Conjugate:Unconjugated
Isotype:IgM
Host Species:Mouse
Storage:Store at 4°C. For long-term storage aliquot and store at -20°C. Avoid freeze/thaw cycles.
Uniprot:Q08722
Background:CD47 (integrin-associated protein, IAP) is an ubiquitously expressed cell surface transmembrane glycoprotein interacting with several integrins and regulating their functions. Engagement of CD47 by soluble ligands or counter receptors modulates various signaling pathways, such as activation of heterotrimeric G proteins. Binding secreted thrombospondin-1, CD47 counteracts graft vascularization. CD47 acts also as a ligand for CD172a (signal regulatory protein ?±, SIRP?±), an immune inhibitory receptor on macrophages; this interaction prevents phagocytosis of CD47-positive cells. Moreover, CD47-CD172a system affects cell migration, B cell adhesion and T cell activation. CD47 is also involved in modulation of chondrocyte responses to mechanical signals, and promotes neuronal development, being especially abundant in synapse-rich regions of brain and retina.
UniProt Protein Function:CD47: Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q13.1-q13.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:protein binding

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; response to bacterium; positive regulation of phagocytosis; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of T cell activation; opsonization; blood coagulation; cell adhesion; leukocyte migration; positive regulation of inflammatory response

NCBI Summary:This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. This gene has broad tissue distribution, and is reduced in expression on Rh erythrocytes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
UniProt Code:Q08722
NCBI GenInfo Identifier:1171879
NCBI Gene ID:961
NCBI Accession:Q08722.1
UniProt Related Accession:Q08722
Molecular Weight:
NCBI Full Name:Leukocyte surface antigen CD47
NCBI Synonym Full Names:CD47 molecule
NCBI Official Symbol:CD47  
NCBI Official Synonym Symbols:IAP; OA3; MER6  
NCBI Protein Information:leukocyte surface antigen CD47
UniProt Protein Name:Leukocyte surface antigen CD47
UniProt Synonym Protein Names:Antigenic surface determinant protein OA3; Integrin-associated protein; IAP; Protein MER6; CD_antigen: CD47
Protein Family:IgE-binding protein
UniProt Gene Name:CD47  
UniProt Entry Name:CD47_HUMAN

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