CD46 Rabbit Monoclonal Antibody (CAB19022)
- SKU:
- CAB19022
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Immunology
Description
Product Name: | CD46 Rabbit Monoclonal Antibody |
SKU: | CAB19022 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD46 (P15529). |
Sequence: | MEPP GRRE CPFP SWRF PGLL LAAM VLLL YSFS DACE EPPT FEAM ELIG KPKP YYEI GERV DYKC KKGY FYIP PLAT HTIC DRNH TWLP VSDD ACYR ETCP |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 |
Synonyms: | MCP; TLX; AHUS2; MIC10; TRA2.10; CD46 |
Positive Sample: | HeLa,MCF7,SW480,A549 |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic vesicle, Single-pass type I membrane protein, acrosome inner membrane, secretory vesicle. |
Calculated MW: | 44kDa |
Observed MW: | 45-75kDa |
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method: | Affinity purification |
Gene ID: | 4179 |
Clone Number: | ARC0428 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |