The CD46 Rabbit Monoclonal Antibody (CAB19022) offered by AssayGenie is a cutting-edge tool for researchers studying the CD46 protein, a key regulator of the immune response. This antibody, developed using rabbit monoclonal technology, boasts high specificity and sensitivity in detecting CD46 in human samples. Validated for use in Western blot applications, it enables precise detection and analysis of CD46 in various cell types.CD46, also known as membrane cofactor protein (MCP), plays a pivotal role in immune regulation by controlling the activation of complement system proteins and T cells.
Dysregulation of CD46 has been implicated in various diseases, including autoimmune disorders, infections, and cancer. By targeting CD46, researchers can gain insights into the mechanisms underlying these conditions and potentially identify therapeutic targets.For immunology and cancer research, the CD46 Rabbit Monoclonal Antibody (CAB19022) from AssayGenie is an invaluable tool for studying the functions and interactions of CD46 in health and disease. Stay ahead in your research with this highly specific and reliable antibody.
Product Name:
CD46 Rabbit Monoclonal Antibody
SKU:
CAB19022
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CD46 (P15529).
Cytoplasmic vesicle, Single-pass type I membrane protein, acrosome inner membrane, secretory vesicle.
Calculated MW:
44kDa
Observed MW:
45-75kDa
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
4179
Clone Number:
ARC0428
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD46 Rabbit mAb (CAB19022) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
