The CD45 Rabbit Monoclonal Antibody (CAB19021) is a valuable tool for researchers studying CD45, a key cell surface antigen involved in immune cell signaling and activation. This antibody, derived from rabbits, is highly specific to human CD45 and has been validated for use in various applications, including Western blot and immunohistochemistry.CD45 plays a crucial role in regulating immune responses and is essential for the proper functioning of the immune system. Dysregulation of CD45 expression or activity has been implicated in various diseases, including autoimmune disorders, infectious diseases, and cancer.
By targeting CD45 with this monoclonal antibody, researchers can accurately detect and investigate CD45 expression in different cell types and tissues, providing valuable insights into immune system function and disease pathology.Whether studying immune cell activation, immune cell development, or immune cell signaling pathways, the CD45 Rabbit Monoclonal Antibody (CAB19021) is a reliable and effective tool for researchers seeking to deepen their understanding of immune biology and advance their research in immunology, cancer biology, and beyond.
Product Name:
CD45 Rabbit Monoclonal Antibody
SKU:
CAB19021
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 194-390 of human CD45 (NP_002829.3).
Membrane, Membrane raft, Single-pass type I membrane protein
Calculated MW:
147kDa
Observed MW:
180-240kDa
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
Purification Method:
Affinity purification
Gene ID:
5788
Clone Number:
ARC0459
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Jurkat cells, using CD45 Rabbit mAb (CAB19021) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
