The CD44 Polyclonal Antibody (CAB23055) is a vital tool for researchers studying CD44, a cell surface glycoprotein involved in cell adhesion and migration. This antibody, generated in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications. By binding to the CD44 protein, this antibody enables the detection and analysis of CD44 expression in various cell types, allowing for in-depth investigations in the fields of immunology, cancer research, and stem cell biology.CD44 is a multifunctional molecule that is implicated in diverse biological processes, such as lymphocyte homing, inflammation, and tumor metastasis. Its role in promoting cellular adhesion, migration, and signaling pathways makes it a valuable target for research into various diseases, including cancer, inflammation, and tissue regeneration.
Understanding the functions of CD44 is crucial for unraveling its complexities and developing potential therapeutic strategies targeting this molecule.The CD44 Polyclonal Antibody (CAB23055) is a reliable tool that enables researchers to explore the diverse functions of CD44 and its implications in various physiological and pathological conditions. Its high specificity and sensitivity in detecting CD44 make it an invaluable asset for studies aiming to elucidate the role of this cell surface molecule in health and disease.
Product Name:
CD44 Polyclonal Antibody
SKU:
CAB23055
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant protein of mouse CD44.
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:100 - 1:500 IF/ICC,1:20 - 1:200
Synonyms:
Ly-24; Pgp-1; HERMES; CD44
Positive Sample:
Mouse lung,Mouse spleen,Rat lung
Conjugate:
Unconjugated
Calculated MW:
86kDa
Observed MW:
80-95kDa
Enables hyaluronic acid binding activity and type II transforming growth factor beta receptor binding activity. Contributes to cytokine binding activity and cytokine receptor activity. Involved in several processes, including negative regulation of T cell activation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including Wnt signaling pathway; morphogenesis of a branching epithelium; and wound healing involved in inflammatory response. Located in basolateral plasma membrane; external side of plasma membrane; and microvillus. Part of macrophage migration inhibitory factor receptor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)).
Purification Method:
Affinity purification
Gene ID:
12505
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using CD44 antibody (CAB23055) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
