The CD44 Polyclonal Antibody (CAB21719) is a vital tool for researchers studying CD44, a cell surface glycoprotein known for its role in cell adhesion and migration. This antibody, generated in rabbits, exhibits high specificity to human samples and is validated for Western blot applications. It targets the CD44 protein, allowing for precise detection and analysis in a variety of cell types, making it a valuable asset for investigations in immunology and cancer research.
CD44 is a multifunctional molecule involved in processes such as cell proliferation, migration, and survival. Its diverse functions make it a key player in various physiological and pathological processes, making it a crucial target for research in cancer, inflammation, and tissue regeneration. Understanding the behavior of CD44 is essential for developing therapeutic interventions that target this molecule in diseases such as cancer and inflammatory disorders.
Product Name:
CD44 Polyclonal Antibody
SKU:
CAB21719
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-178 of CD44 (NP_000601.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
82kDa
Observed MW:
82kDa/80kDa
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Purification Method:
Affinity purification
Gene ID:
960
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse spleen using CD44 Rabbit pAb(CAB21719) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection:ECL Basic Kit (AbGn00020).Exposuretime:15s.
