The CD44 Polyclonal Antibody (CAB0340) is a valuable tool for research related to CD44, a cell surface glycoprotein involved in cell adhesion, migration, and signaling. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. It specifically binds to the CD44 protein, allowing for precise detection and analysis in various cell types.CD44 is known for its diverse functions in cell-cell interactions, lymphocyte homing, and tumor metastasis, making it a key player in cancer research and immunology studies. By targeting CD44, researchers can gain insights into its role in tumor progression, immune response modulation, and cellular signaling pathways.
The CD44 Polyclonal Antibody is a valuable tool for investigating the mechanisms underlying these processes and developing potential therapeutic strategies for cancer and immune-related disorders.In conclusion, the CD44 Polyclonal Antibody is a reliable reagent for researchers studying CD44 biology and its implications in cancer and immunology. Its high reactivity and specificity make it suitable for a wide range of experimental applications, providing valuable insights into the functions of CD44 in various physiological and pathological contexts.
Product Name:
CD44 Rabbit Polyclonal Antibody
SKU:
CAB0340
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 346-385 of CD44 (NP_000601.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
82kDa
Observed MW:
80kDa
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Purification Method:
Affinity purification
Gene ID:
960
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from ECV-304 cells, using CD44 Rabbit pAb (CAB0340) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 0.5s.
