The CD44 Antigen Polyclonal Antibody (CAB1351) is a valuable tool for researchers studying the CD44 antigen, a cell surface glycoprotein involved in cell adhesion and migration. This antibody, raised in rabbits, exhibits high reactivity with human samples and is specially validated for use in Western blot applications. By binding to the CD44 antigen, this antibody allows for the precise detection and analysis of CD44 expression in various cell types, making it an excellent choice for studies in immunology, cancer research, and stem cell biology.CD44 is known to play a crucial role in processes such as cell proliferation, migration, and differentiation, making it a key player in various physiological and pathological conditions.
Its overexpression has been linked to cancer progression and metastasis, making it a promising target for cancer therapy research. Additionally, CD44 has been implicated in inflammation and immune response modulation, highlighting its potential importance in autoimmune diseases and chronic inflammatory conditions.The CD44 Antigen Polyclonal Antibody (CAB1351) is a valuable tool for researchers aiming to better understand the role of CD44 in these complex biological processes. Its high specificity and sensitivity make it an ideal choice for experiments seeking to uncover the molecular mechanisms underlying CD44-mediated cellular functions.
Product Name:
CD44 Rabbit Polyclonal Antibody
SKU:
CAB1351
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-178 of CD44 (NP_000601.3).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
82kDa
Observed MW:
82kDa
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Purification Method:
Affinity purification
Gene ID:
960
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD44 Rabbit pAb (CAB1351) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
