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CD41a monoclonal antibody (FITC) (AGIM0319)

SKU:
AGIM0319
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
HIP8
Conjugation:
FITC
Applications:
FC
€179
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Description

system_update_altDatasheet
Product Name:CD41a monoclonal antibody (FITC)
Product Code:AGIM0319
Size:100 µL
Reactivity:Human
Clone:HIP8
Applications:Flow Cytometry
Conjugate:FITC
Isotype:IgG1
Host Species:Mouse
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P08514
Background:CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.
UniProt Protein Function:ITGA2B: Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognizes the sequence R-G-D in a wide array of ligands. It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha- IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Belongs to the integrin alpha chain family. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-IIb associates with beta-3. Directly interacts with RNF181. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.31

Cellular Component: cell surface; integral to plasma membrane; plasma membrane; platelet alpha granule membrane

Molecular Function:identical protein binding; protein binding

Biological Process: cell adhesion; extracellular matrix organization and biogenesis; integrin-mediated signaling pathway; platelet degranulation

Disease: Bleeding Disorder, Platelet-type, 16; Glanzmann Thrombasthenia

NCBI Summary:This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia. [provided by RefSeq, Jan 2016]
UniProt Code:P08514
NCBI GenInfo Identifier:226694183
NCBI Gene ID:3674
NCBI Accession:P08514.3
UniProt Secondary Accession:P08514,O95366, Q14443, Q17R67, B2RCY8,
UniProt Related Accession:P08514
Molecular Weight:113kDa
NCBI Full Name:Integrin alpha-IIb
NCBI Synonym Full Names:integrin subunit alpha 2b
NCBI Official Symbol:ITGA2B  
NCBI Official Synonym Symbols:GT; GTA; CD41; GP2B; HPA3; CD41B; GPIIb; BDPLT2; BDPLT16; PPP1R93  
NCBI Protein Information:integrin alpha-IIb
UniProt Protein Name:Integrin alpha-IIb
UniProt Synonym Protein Names:GPalpha IIb; GPIIb
Protein Family:Integrin
UniProt Gene Name:ITGA2B  

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